SNF: Denver Broncos vs San Francisco 49ers 9/25/22 NFL Picks, Predictions, Odds

San Francisco 49ers (1-1) vs. Denver Broncos (1-1)
September 25, 2022 8:20 pm EDT
The Line: Denver Broncos +1 / San Francisco 49ers -1; Over/Under: +46
(Click here for latest betting odds)

The Denver Broncos and San Francisco 49ers clash Sunday in a week 3 NFL SNF matchup from Empower Field at Mile High.

The San Francisco 49ers will look to build on their 27-7 win over the Seattle Seahawks last time out. Jimmy Garoppolo has thrown for 154 yards and a touchdown on 61.9% passing while Jeff Wilson Jr. and Deebo Samuel each have 100+ rushing yards this season. Brandon Aiyuk also has 103 receiving yards to lead the 49ers’ receiving corps this season. On defense, Talanoa Hufanga has a team-high 17 total tackles including 14 solo tackles while Nick Bosa has a team-high 3 sacks and the 49ers as a team have 3 interceptions this season.

The Denver Broncos will look to build on their 16-9 win over the Houston Texans in their last game. Russell Wilson’s thrown for 559 yards, 2 touchdowns and an interception on 58.9% passing while Melvin Gordon III and Javonte Williams have combined for 223 rushing yards so far. Courtland Sutton leads Denver’s receiving group with 11 grabs for 194 receiving yards while Jerry Jeudy has 113 receiving yards this season. On defense, Alex Singleton has a team-high 14 total tackles while Bradley Chubb and Dre’Mont Jones each have a pair of sacks so far this season.

San Francisco is 6-1 ATS in their last 7 games overall and 4-1 ATS in their last 5 road games while the under is 5-0 in their last 5 games overall. Denver is 1-5 ATS in their last 6 games overall and 0-4 ATS in their last 4 games following a win while the under is 10-3 in their last 13 games overall.

I get the case to be made for the Broncos here, but the line is already on the move and I definitely think it’s a justified move. The 49ers showed that they can be a legit team when they’re not playing in a monsoon and while it happened under unfortunate circumstances, Jimmy G finally gets to bet on himself here. Denver obviously has a solid team let by Russell Wilson, but we’ve yet to see them gel as a unit and until it happens, it’s going to be hard to back them, especially in a pick ‘em spot like this. Give me the 49ers here.

Chris Ruffolo's Free Pick:
San Francisco -1
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